Abner Beal is a stuffy professor in a lifeless marriage, but he's just made the scientific breakthrough of the century: A serum that temporarily turns organic matter invisible. Testing it on himself, he discovers that his beautiful neighbor has left her window open—and is longing for someone, anyone, to satisfy her. This stuffy professor is about to become a very naughty invisible man!

Having cracked the code to invisibility, Professor Abner Beal returns to the Institute to solicit the aid of one Priscilla Coker, M.D. Priscilla hates Abner, but when she learns that he's made a breakthrough, she's willing to do anything to join his team—even jumping his invisible bones! But that's not the only surprise waiting for Professor Beal. Upon returning to his house, Abner discovers that his wife has been having an affair of her own.

Something is happening to Dr. Abner Beal. He's spent the last nine years developing a serum to turn soldiers invisible, and now he's finally done it. It was his life's work...but his life isn't over. For the first time in years, Abner's heart is overcome with emotion. He feels strange and vulnerable, and alone. When his wife decides to separate from him, he finds himself torn between two very different women: His seductive co-worker who wants him for his brain, and his daughter's best friend who wants him for his body. What is a naughty invisible man to do?